Isomorphic copolyoxalates and sutures thereof
US4141087A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1977 |
| Grant date | Feb 27, 1979 |
| Priority date | — |
| Expiry date | Jan 19, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2017/00004
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Synthetic absorbable sutures are prepared from copolyoxalate polymers having isomorphic sequences. The polymers are derived from mixtures of cyclic and linear diols, each having the same carbon chain length of 6 or 8 atoms. The cyclic diol may be aliphatic or aromatic. The diols are polymerized with dialkyl oxalate, preferably in the presence of an inorganic or organometallic catalyst, to obtain a highly crystalline isomorphic copolyoxalate polymer which is melt extruded and drawn to form oriented filaments. The filaments are characterized by good initial tensile and knot strength and a high order of softness and flexibility. When implanted in living animal tissue, the fibers have good strength retention over a period of at least 21 days and eventually absorb with a minimal degree of adverse tissue reaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.