N-dealkylation of N-alkyl-14-hydroxymorphinans and derivatives thereof
US4141897A · kind A · utility
37Cited by
7References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 20, 1976 |
| Grant date | Feb 27, 1979 |
| Priority date | — |
| Expiry date | Dec 20, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D221/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is provided a novel, high yield, method of dealkylating N-alkylated 14-hydroxymorphinans and derivatives thereof including, inter alia, oxymorphone and oycodone. There are thus provided, inter alia, more efficient routes for the formation of naloxone, naltrexone, and nalbuphine. In the principal step of the process, the dealkylation using certain oxycarbonyl halides (or haloformates) is carried out on the N-alkyl-14-acyloxy-morphinan which it is desired to dealkylate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.