2-Acyl-4-oxo-pyrazino-isoquinoline derivatives and process for the preparation thereof

US4141978A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Jurgen Seubert · Darmstadt, DE
• Herbert Thomas
• Peter Andrews · Wuppertal, DE

Key dates

• Filing date: Nov 15, 1976
• Grant date: Feb 27, 1979
• Expiry date: Nov 15, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1-a]isoquinoline with an acid or a reactive functional derivative thereof.