Process for producing 17-acetals of 3-alkoxyestra-2,5 (10)-dien-17-ones
US4143040A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 21, 1977 |
| Grant date | Mar 6, 1979 |
| Priority date | — |
| Expiry date | Nov 21, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J1/0081
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
17-Ketals of 3-alkoxyestra-2,5(10)-dien-17-ones are prepared by reacting 17-ketals of 3-alkoxyestra-1,3,5(10)-trien-17-ones with sodium or potassium, liquid ammonia and a tertiary alcohol in the presence of an alicyclic hydrocarbon and/or an aliphatic hydrocarbon, and a solvent selected from the group consisting of tetrahydrofuran, dioxane and tetrahydropyran. Yield and selectivity of this reaction are improved by using the 17-ketal of the 3-alkoxyestra-1,3,5(10)-trien-17-one, sodium or potassium, liquid ammonia and the solvent in such proportions that the 17-ketal of the 3-alkoxyestra-1,3,5(10)-trien-17-one is substantially dissolved in the reaction system and that two liquid phases are formed, the lower phase being colored.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.