Substituted azetidin-2-one antibiotics
US4144232A · kind A · utility
27Cited by
2References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 30, 1977 |
| Grant date | Mar 13, 1979 |
| Priority date | — |
| Expiry date | Nov 30, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Monocyclic .beta.-lactam antibiotics of the formula ##STR1## WHEREIN R is amino or acylamino, e.g., phenylacetylamino, phenylglycylamino and 2-[4-(3-amino-3-carboxypropoxy)phenyl]-2-hydroximinoacetylamino; R.sub.1 is H or ester forming group; R.sub.2 is H, --OCH.sub.3, --SCH.sub.3, or --CH.sub.3 ; and R.sub.3 is H or acetoxy; are useful antibacterials for controlling .beta.-lactamase producing gram-negative bacteria and other pathogens. Intermediates useful in the preparation of the antibiotics and a novel process for preparing 4.alpha.-acetoxy substituted azetidin-2-ones are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.