6-Deoxy-6-azido-14-hydroxy-7,8-dihydroisomorphine or a pharmaceutically acceptable salt thereof
US4144236A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 10, 1977 |
| Grant date | Mar 13, 1979 |
| Priority date | — |
| Expiry date | May 10, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of pharmaceutically acceptable 3-protected derivatives of 6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine, selected from the group which consists of 3-O-acetyl-6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine, 3-O-tetrahydropyranyl-6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine and 3-O-methylenemethoxy-6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine, and the salts of these compounds which comprise the following steps: PA0 Blockin the hydroxy in position 3 of 14-hydroxy-7, 8-dihydromorphine with a moiety selected from the group which consists of acetyl, tetrahydropyranyl, and methylenemethoxy; and PA0 Azidiylating position 6 of the compounds formed in a step (a) thereby removing the hydroxy formerly in that position.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.