Antimicrobial fatty acid derivatives

US4144256A · kind A · utility

Assignee

• The United States of America, as represented by the Secretary of Agriculture · US

Inventors

• Robert R. Mod · New Orleans, US
• James A. Harris · Pearl River, US
• Jett C. Arthur, Jr. · Metairie, US
• Frank C. Magne · Metairie, US
• Gene Sumrell · New Orleans, US
• Arthur F. Novak · Baton Rouge, US

Key dates

• Filing date: May 10, 1978
• Grant date: Mar 13, 1979
• Expiry date: May 10, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C327/00
• WIPO field: Basic materials chemistry
• WIPO sector: Chemistry

Abstract

Acetylthio amides and esters were prepared by the free radical addition of thiolacetic acid to the terminal and nonterminal double bonds of N-substituted fatty amides and fatty esters. The free radical additions of the thiolacetic acid to the unsaturated compounds were initiated by irradiation using cobalt-60. The process using irradiation with cobalt-60 was also used to bring about the addition of bromotrichloromethane to N-substituted fatty amides and fatty esters to produce halogen-containing amides and esters. These new sulfur or halogen-containing compounds were found to have antimicrobial activity and to possess properties making them useful as antimicrobial agents.