Process for the manufacture of m-trifluoromethyl benzyl nitrile
US4144265A · kind A · utility
2Cited by
3References
7Claims
0Family size
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Key dates
| Filing date | Jul 17, 1978 |
| Grant date | Mar 13, 1979 |
| Priority date | — |
| Expiry date | Jul 17, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C255/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Quaternary ammonium salts, such as methyl tributyl ammonium chloride, are novel catalysts in a nitrile-forming reaction which comprises stirring together aqueous sodium cyanide and the undistilled m-trifluoromethyl benzyl chloride product of the reaction of chloromethyl methyl ether, chlorosulfonic acid and trifluoromethyl benzene from which chloromethyl ether impurities, methanol, water and some of the unreacted trifluoromethyl benzene are removed. The process is conducted under alkaline conditions in a two-phase liquid reaction medium. m-Trifluoromethyl benzyl nitrile is prepared in excellent yields and purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.