2-Benzopyranone derivatives, process for their production, their use as medicaments, more especially as coronary dilators

US4144336A · kind A · utility

Assignee

• Troponwerke Dinklage & Co. · DE

Inventors

• Karl-Heinz Boltze · Borod, DE
• Peter-Rudolf Seidel · Cologne, DE
• Haireddin Jacobi · Leichlingen, DE
• Helmut Schwarz · Ludwigshafen, DE

Key dates

• Filing date: Jul 8, 1976
• Grant date: Mar 13, 1979
• Expiry date: Jul 8, 1996

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel 2-benzopyranone compounds of the formula ##STR1## wherein X is a 3,4,5-trimethoxybenzoyl group or a 3,4,5-trimethoxycinnamoyl group; and each PA1 R individually is selected from the group consisting of alkylamino and dialkylamino in which one carbon atom in the alkyl moiety may be replaced by an oxygen atom and one hydrogen atom may be replaced by a hydroxyl group which may in turn be esterified with a 3,4,5-trimethoxybenzoyl or 3,4,5-trimethoxycinnamoyl group; amino substituted once or twice by alkenyl, aralkyl, or cycloalkyl; or a 4- to 7-membered N-containing heterocyclic ring linked through a nitrogen atom and which contains up to 3 hetero atoms, which heterocyclic ring may be substituted by phenyl, alkyl or hydroxyalkyl, wherein the hydroxy group may be esterified by a 3,4,5-trimethoxy benzoyl or 3,4,5-trimethoxy cinnamoyl group; Or a salt of each compound with a physiologically acceptable acid; possess outstanding activity as coronary dilators. Processes for producing such compounds are also disclosed.