Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases

US4145442A · kind A · utility

Assignee

• Aktiebolaget Hassle · SE

Inventors

• Peder Bernhard Berntsson
• Arne E. Brandstrom · Gothenburg, SE
• Enar I. Carlsson · Mölndal, SE
• Stig Ake Ingemar Carlsson
• Lars Ek
• Benny Roger Samuelsson
• Sven E. Sjostrand · Kungsbacka, SE
• Gert Strandlund · Lindome, SE
• Bengt Arne Hjalmar Ablad · Göteborg, SE

Key dates

• Filing date: Aug 31, 1976
• Grant date: Mar 20, 1979
• Expiry date: Aug 31, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/088
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R.sup.1 is alkyl or hydroxyalkyl, R.sup.2 is alkoxyalkyl or alkylthioalkyl, and R.sup.3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed, as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.