Antiarrhythmic quinuclidine carboxylic acid xylidide and method of producing the same and similar compounds
US4146628A · kind A · utility
Inventors
Key dates
| Filing date | Aug 4, 1977 |
| Grant date | Mar 27, 1979 |
| Priority date | — |
| Expiry date | Aug 4, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/445
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the compound 2-6-xylidide of quinuclidine-3-carboxylic acid and its pharmaceutically acceptable salts, such as the hydrochloride, which have been found to be effective antiarrhythmic agents. The invention further relates to the production of this antiarrhythmic compound which method is applicable also to the production of related compounds which, however, do not have antiarrhythmic action, e.g. the quinuclidine-2-carboxylic acid xylidides. The compounds are produced according to this method by reacting the quinuclidine carboxylic acid in anhydrous chloroform and oxalyl chloride with the dimethylaniline. The desired compound is produced in high yield with a high degree of purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.