Blood pressure lowering and adrenergic .beta.-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers

US4146630A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Wolfgang Kampe
• Walter-Gunar Friebe · Mannheim, DE
• Fritz Wiedemann · Weinheim, DE
• Gisbert Sponer · Hemsbach, DE
• Wolfgang Bartsch · Viernheim, DE
• Karl Dietmann

Key dates

• Filing date: Oct 27, 1977
• Grant date: Mar 27, 1979
• Expiry date: Oct 27, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A 3-(4-phenoxymethylpiperidino)-propyl-phenyl-ether of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently is hydrogen, lower alkyl, hydroxyalkyl, lower alkanoyloxyalkyl or --CO--Z, PA1 Z is hydroxy, lower alkyloxy or ##STR2## R.sub.6 and R.sub.7 each independently is hydrogen, lower alkyl or hydroxyalkyl, PA1 R.sub.3 is hydrogen or --O--R.sub.8, PA1 R.sub.8 is hydrogen, lower alkanoyl or aroyl optionally substituted by halogen, lower alkyl, lower alkoxy, alkoxycarbonyl, hydroxyl, alkylthio, nitrile, nitro or trifluoromethyl, PA1 R.sub.4 and R.sub.5 each independently is hydrogen, halogen, hydroxy, benzyloxy, lower alkyl, lower alkoxy, lower alkylthio, carboxy, benzyloxycarbonyl or lower alkoxycarbonyl, PA1 X and Y each independently is nitrogen or ##STR3## R.sub.9 is hydrogen, lower allkyl optionally substituted by --O--R.sub.8, or --CO--Z, or a pharmacologically acceptable salt thereof. The compounds lower blood pressure and inhibit adrenergic .beta.-receptors.