Substituted phenyl-amidines
US4146647A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 25, 1977 |
| Grant date | Mar 27, 1979 |
| Priority date | — |
| Expiry date | Jan 25, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides compounds of the formula: ##STR1## in which A is CH.sub.2, CHOH, CH.sub.2 O, CH.sub.2 S, CH.sub.2 NH, OCH.sub.2, SCH.sub.2, NH, NHCH.sub.2, NHCOCH.sub.2 or CH.sub.2 NHCH.sub.2, X.sub.1 is H, halogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, X.sub.2 is halogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, Z is 2-pyrimidinyl or C(.dbd.NR.sub.1)NHR.sub.2 (where R.sub.1 is H and R.sub.2 is H, OH or CH.sub.2 CO.sub.2 Et, or R.sub.1 and R.sub.2 together form CH.sub.2 CH.sub.2, CH.sub.2 CH.sub.2 CH.sub.2 or N.dbd.N), and their addition salts. The compounds of formula I and their salts are useful in therapy as hypotensive agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.