Method of preparing a rapidly dissolving powder of sterile crystalline cefazolin sodium for parenteral administration
US4146971A · kind A · utility
8Cited by
2References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 14, 1977 |
| Grant date | Apr 3, 1979 |
| Priority date | — |
| Expiry date | Dec 14, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Sterile, essentially crystalline cefazolin sodium for parenteral administration is prepared by a freeze-drying process wherein a C.sub.1 -C.sub.3 alcohol-water solution of cefazolin sodium containing about 10 percent by volume of the C.sub.1 -C.sub.3 alcohol is chilled slowly from room temperature to about -10.degree. C. over a 3-12 hour period and then rapidly cooled to -30.degree. to about -40.degree. C. and held for 1-2 hours before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the frozen solvent therefrom. The resulting powder dissolves rapidly in acceptable pharmaceutical diluents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.