.beta.-Lactam precursors of penicillin and cephalosporin antibiotics
US4147699A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 29, 1977 |
| Grant date | Apr 3, 1979 |
| Priority date | — |
| Expiry date | Dec 29, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides novel .beta.-lactam precursors of known and novel microbiologically active penicillins and cephalosporins and to a process for making the .beta.-lactam precursors from a L-cysteinylvaline dipeptide or a polypeptide containing the L-cysteine with other amino acids. The .beta.-lactam precursors are represented by the Formula I. ##STR1## wherein Z is ##STR2## and wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are defined herein. When Z has the structure of Formula A, the .beta.-lactam is a precursor for cephalosporins. When Z has the structure of either Formula B or Formula C, the .beta.-lactam is a precursor for a penicillin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.