1-(3-Hydroxyalk-1-yl)-5-(carboxyalkyl)hydantoin derivatives

US4147796A · kind A · utility

Assignee

• Beecham Group · GB

Inventor

• Gordon Wootton · Sawbridgeworth, GB

Key dates

• Filing date: Jun 14, 1978
• Grant date: Apr 3, 1979
• Expiry date: Jun 14, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/86
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of formula (I): ##STR1## wherein: X is O or S; PA1 n is 1 to 8; PA1 R.sub.1 is hydrogen, or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1-12 carbon atoms; PA1 R.sub.2 is hydrogen, C.sub.1-4 alkyl, or phenyl; PA1 R.sub.3 is hydroxy or protected hydroxy, PA1 R.sub.4 is hydrogen, C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cyclo alkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, naphthyl, naphthyl-C.sub.1-6 -alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkoxy, phenyl C.sub.1-6 alkoxy or nitro groups; or PA1 R.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; PA1 R.sub.5 is C.sub.1-6 alkyl, C.sub.1-6 alkyl substituted by a nitro, hydroxy, C.sub.1-6 alkoxy, CO.sub.2 A, (CO.sub.2 A).sub.2, CN or halogen group, C.sub.5-8 cycloalkyl, phenyl, phenyl, phenyl-C.sub.1-6 alkyl, phenyl-C.sub.3-6 cycloalkyl, any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or nitro groups; or a group CO.sub.2 A; in R.sub.5 w…