Antidiuretically effective polypeptide and a process for preparing the same
US4148787A · kind A · utility
8Cited by
3References
4Claims
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Key dates
| Filing date | Nov 8, 1977 |
| Grant date | Apr 10, 1979 |
| Priority date | — |
| Expiry date | Nov 8, 1997 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/15
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antidiuretically effective vasopressin derivates of the formula ##STR1## in which Mep is a 2-mercaptopropionyl residue (--S--CH.sub.2 CH.sub.2 CO--), and A and B are glutamine (Gln) or asparagine (Asn) and A is Gln only when B is Gln and D-arginine is in position 8. A method for preparing the derivatives comprises the steps of gradually producing the amino acid sequence EQU Mep(SH)--Tyr--Phe--A--B--Cys(SH)--Pro--D--Arg--Gly--NH.sub.2 and thereafter oxidizing this amino acid sequence to the desired vasopressin derivative of the formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.