Mixture of antibiotics produced by a species of actinoplanes

US4148880A · kind A · utility

Assignee

• PFIZER INC. · US

Inventors

• Walter D. Celmer · New London, US
• Walter P. Cullen · East Lyme, US
• Charles E. Moppett · Mystic, US
• John B. Routien · East Lyme, US
• Riichiro Shibakawa · Handa, JP
• Junsuke Tone · Chita, JP

Key dates

• Filing date: Dec 16, 1976
• Grant date: Apr 10, 1979
• Expiry date: Dec 16, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07G11/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery. This mixture of antibiotics is also produced by a species of Actinoplanes designated Actinoplanes azureus ATCC 31157. In addition, this culture produces a mixture of heptaene antibiotics with antifungal properties.