Process for preparing cephem lactones for cephalosporin-type antibiotics
US4148995A · kind A · utility
1Cited by
3References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 18, 1977 |
| Grant date | Apr 10, 1979 |
| Priority date | — |
| Expiry date | Jul 18, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D205/095
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Cephem lactones of formula (1) ##STR1## wherein R.sup.1 is hydrogen or an organic substituent of the type appearing as the 6-substituent of penicillins or as the 7-substituent of cephalosporins are produced from corresponding 4,5-halohydrin precursors thereof by dehalogenation. Novel stereoisomers of formula (1) compounds as well as novel intermediates for cephem lactone syntheses are disclosed. The cephem lactones produced according to the invention are of utility as intermediates for cephem-type antibiotics and have antibiotic properties of their own.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.