Patent · US Expired

Immunization against dental caries with glucosyltransferase antigens

US4150116A · kind A · utility

36Cited by
1References
8Claims
0Family size

Assignee

Inventors

Key dates

Filing dateFeb 21, 1978
Grant dateApr 17, 1979
Priority date—
Expiry dateFeb 21, 1998

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K39/092
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Immunization of animals with preparations containing more purified forms of glucosyltransferase (GTF) results in the presence of antibody in saliva demonstrable by functional inhibitions of enzyme activity and binding of radioactive enzyme. Serum antibody was also present. Immunized groups of animals had lower mean caries scores than comparably sham-immunized or nonimmunized control groups. Local immunization with GTF of serotype c or g or a Streptococcus mutans reduces the colonization, caries, and lesions caused by infection with S. mutans of serotype g (strain 6715) or c, or with serotype g or c, or with serotype a or g, respectively.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.