Novel steroid compounds having an oxygen function in the 19-position
US4150127A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 3, 1977 |
| Grant date | Apr 17, 1979 |
| Priority date | — |
| Expiry date | Oct 3, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 19-oxygenated steroids of the 20-spiroxane series of the formula ##STR1## in which R.sup.3 is a lower alkyl radical carrying an oxygen-containing functional group and R.sup.4 is two hydrogen atoms or an oxo group, and which carry a double bond or a methylene group in the 6,7-position or carry a lower alkanoylthio group in the 7.alpha.-position, and the corresponding 17.beta.-hydroxy-21-carboxylic acids of the formula ##STR2## in which R.sup.3 is as defined above, and which carry a double bond or a methylene group in the 6,7-position, as well as salts thereof and 1,2-dehydro derivatives of all of these compounds are advantageous as potassium-saving diuretics in therapy since they antagonize the physiological effects of aldosterone but have only slight side effects on sexual functions of the body. The compounds are obtainable by conventional general preparation processes of steroid chemistry.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.