1-(3-Hydroxyalk-1-yl)-5-(carboxyalkyl)hydantoin derivatives
US4152445A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 14, 1978 |
| Grant date | May 1, 1979 |
| Priority date | — |
| Expiry date | Jun 14, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/86
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of formula (I) ##STR1## wherein: X is O or S; PA1 n is 1 to 8; PA1 R.sub.1 is hydrogen, or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1-12 carbon atoms; PA1 R.sub.2 is hydrogen, C.sub.1-4 alkyl, or phenyl; PA1 R.sub.3 is hydroxy or protected hydroxy; PA1 R.sub.4 is hydrogen, C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, naphthyl, naphthyl-C.sub.1-6 -alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkoxy, phenyl C.sub.1-6 alkoxy or nitro groups; or PA1 R.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; and salts thereof; has useful pharmacological activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.