Process for the production of 4,5-disubstituted thiazoles

US4153607A · kind A · utility

Assignee

• BASF SE

Inventors

• Heinz Eilingsfeld · Bischofswerda, DE
• Guenther Seybold · Schifferstadt, DE

Key dates

• Filing date: Feb 24, 1978
• Grant date: May 8, 1979
• Expiry date: Feb 24, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/56
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4,5-Disubstituted thiazoles are manufactured by reacting 4-amino-5-cyano-thiazoles with hydrogen sulfide in the presence of basic compounds, followed by dehydrogenating cyclization. The new 3-amino-thiazolo-(4,5-c)-isothiazoles I, 4-amino-5-thiocarbamidothiazoles III and 4,5-disubstituted thiazoles IV obtainable by the process of the invention are valuable intermediates for the manufacture of azo dyes and of crop protection agents.