Immunizing and anti-infectious adjuvant agents constituted by N-acetyl-muramyl-L-alanyl-D-glutamic acid derivatives
US4153684A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 7, 1977 |
| Grant date | May 8, 1979 |
| Priority date | — |
| Expiry date | Mar 7, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/5555
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to new water-soluble agents which are effective as immunizing adjuvants. These adjuvant agents are the methyl, ethyl or propyl esters of 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-isoglu tamine and of 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-glutam ic acid, the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-(.alph a.-methylamide)-glutamic and 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-seryl-D-isoglut amine, the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-seryl-D-glutami c acid and their derivatives. They are particularly useful to prepare adjuvant medicinal compositions, used for increasing the efficiency of vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.