Trifluoromethylated oligopeptides
US4153688A · kind A · utility
18Cited by
1References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 9, 1978 |
| Grant date | May 8, 1979 |
| Priority date | — |
| Expiry date | Feb 9, 1998 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound having the formula ##STR1## wherein (1) --X--Y-- is -L-Ala-L-Ala- and R is H, m-NO.sub.2, m-CF.sub.3, p-Cl, p-NO.sub.2, p-CF.sub.3, p-OCH.sub.3, p-CH(CH.sub.3).sub.2, p-CN or p-COOH, PA0 (2) --x--y-- is -L-Lys-L-Ala- and R is H, p-CF.sub.3, p-CH.sub.3 p-CH(CH.sub.3).sub.2, ##STR2## or p-COCH.sub.3 (3) --X--Y-- is ##STR3## AND R is H, or (4) --X--Y-- is -L-Lys-L-Lys or L-Ala-L-Lys and R is p-CF.sub.3. The compounds are reversible inhibitors of porcine pancreatic elastase and human lentocytal elastase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.