Behenic acid esters, compositions thereof and a method of preparation thereof
US4153694A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 19, 1977 |
| Grant date | May 8, 1979 |
| Priority date | — |
| Expiry date | Aug 19, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel behenic acid esters of the following general formula: ##STR1## wherein X is "N" or "CH," the non-toxic acid addition salts thereof, a method for the preparation of said esters and therapeutic compositions thereof having prolonged effect. It is an object of the present invention to provide behenic acid esters of Formula I, a method of making the same, a method for the alleviation, palliation, mitigation or inhibition of the manifestations of certain physiological-psychological abnormalities of animals therewith, and pharmaceutical compositions comprising such compounds as active ingredient. Other objects will be apparent to one skilled in the art and still other objects will become apparent hereinafter. PAC BACKGROUND OF THE INVENTION In recent years esters of neuroleptic active phenothiazines have been suggested and found useful in preparations having prolonged effect when administered parenterally, The esters which have been found most useful are enanthic, decanoic and palmitic acid esters of fluphenazine which are mostly administered as sterile solutions in vegetable oils which solutions are injected intramuscularly. The neuroleptic effect o…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.