Aminoalkyl-substituted benzoxazine derivatives

US4154829A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Anton Mentrup · Mainz, DE
• Kurt Schromm · Ingelheim am Rhein, DE
• Ernst-Otto Renth · Ingelheim am Rhein, DE
• Richard Reichl · Ingelheim am Rhein, DE
• Werner Traunecker · Münster-Sarmsheim, DE
• Wolfgang Hoefke · Wiesbaden, DE

Key dates

• Filing date: Mar 2, 1977
• Grant date: May 15, 1979
• Expiry date: Mar 2, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D265/36
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Racemic and optically active compounds of the formula EQU Q--C.sub.n H.sub.2n --NH--R wherein Q is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino, PA1 R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl, PA1 R.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy, and PA1 A is --O--, --CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 -- where the oxygen is bonded to the benzene ring, or --NR.sub.3 -- where R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms, PA1 N is an integer from 2 to 6, inclusive, and PA1 R is hydrogen, benzyl or ##STR2## where R.sub.4 is hydrogen, methyl or ethyl, PA1 R.sub.5, r.sub.6 and R.sub.7, which may be identical to or different from each other, are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR.sub.3, --CONHOH, --COOR.sub.3, R.sub.8 O--, methylsulfonylmethyl or, when one or two of R.sub.5 through R.sub.7 are other than halogen or trifluoromethyl, also --NR.sub.3 R.sub.9, PA2 where PA2 R.sub.3 has the meaning…