(Aminoalkoxy-aryl)-substituted isoquinolinones and naphthydrinones and salts thereof, and hypotensive compositions and methods employing them

US4154837A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Joachim Heider · Warthausen, DE
• Volkhard Austel · Biberach, DE
• Wolfgang Eberlein · Biberach, DE
• Rudolf Kadatz · Zell am Harmersbach, DE
• Jurgen Dammgen · Sulmingen, DE
• Walter Kobinger · Wien, AT
• Christian Lillie · Wien, AT

Key dates

• Filing date: Jan 6, 1978
• Grant date: May 15, 1979
• Expiry date: Jan 6, 1998

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein A is benzo, mono-, di- or tri-substituted benzo, the substituents being selected from the group consisting of lower alkoxy, amino and nitro, or pyrido; PA1 R.sub.1 is hydrogen or lower alkyl; PA1 R.sub.2 is alkyl of 1 to 6 carbon atoms or --X--R.sub.6, PA1 where X is straight alkylene of 1 to 4 carbon atoms or hydroxy-substituted straight alkylene of 1 to 4 carbon atoms; and PA2 R.sub.6 is amino; carbalkoxy of 2 to 6 carbon atoms; phenyl; mono-, di- or tri-substituted phenyl, the substituents being selected from the group consisting of lower alkyl and lower alkoxy; phenoxy; or mono-, di- or tri-substituted phenoxy, the substituents being selected from the group consisting of lower alkyl and lower alkoxy; PA1 R.sub.3 is hydrogen or hydroxyl; PA1 R.sub.4 is hydrogen, lower alkyl or lower alkoxy; PA1 R.sub.5 is hydrogen or lower alkyl; and PA1 N is 0, 1 or 2; And non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as antiarrhythmics, .beta.-adrenergic-receptor blockers and anti-anginous agents.