2,6-Dimethyl -3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine

US4154839A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Egbert Wehinger
• Friedrich Bossert
• Arend Heise · Wuppertal, DE
• Stanislav Kazda · Wuppertal, DE
• Kurt Stoepel · Wuppertal, DE
• Wulf Vater

Key dates

• Filing date: May 8, 1978
• Grant date: May 15, 1979
• Expiry date: May 8, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate demonstrates the unique ability of increasing myocardial perfusion upon oral or intravenous administration. Methods of preparing the compound, its use in coronary conditions and pharmaceutical compositions for effecting that use are disclosed.