Carbohydrate derivatives of milbemycin and processes therefor

US4156720A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Michael H. Fisher · Bound Brook, US
• Richard L. Tolman · Hackettstown, US

Key dates

• Filing date: Nov 17, 1977
• Grant date: May 29, 1979
• Expiry date: Nov 17, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H17/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Carbohydrate derivatives of the antibiotic substance milbemycin, also identified as B-41, and of 13-hydroxy milbemycin are prepared. The carbohydrate groups are attached to the available hydroxy groups of milbemycin and to the hydroxy group synthesized at the 13-position. The reactions may be made selectively such that more than one carbohydrate group may be attached to a single position, or that multiple carbohydrate groups may be attached at different positions on the molecule. The described carbohydrate derivatives have antiparasitic activity.