Pharmaceutically active compounds, preparation thereof, intermediates useful in such preparation and compositions containing the compounds

US4156730A · kind A · utility

Assignee

• Beecham Group · GB

Inventors

• Richard W. Moore · Chelmsford, GB
• Frederick Cassidy · Harlow, GB
• Gordon Wootton · Sawbridgeworth, GB

Key dates

• Filing date: May 13, 1977
• Grant date: May 29, 1979
• Expiry date: May 13, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of formula (I): ##STR1## wherein: M IS 0 OR 1; PA1 N is 4 to 8; PA1 A is hydrogen, and when m is 0 and R.sub.5 is methyl it may also be methyl or a group CO.sub.2 B wherein B is hydrogen or CO.sub.2 B represents an ester group in which the B moiety contains from 1 to 12 carbon atoms; PA1 X is CO, protected CO, CROH in which R is hydrogen or C.sub.1-4 alkyl and in which the OH moiety may be protected; R.sub.1 is hydrogen, or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains 1 to 12 carbon atoms; PA1 R.sub.4 is hydrogen, C.sub.1-9 alkyl, C.sub.5-8 cycloalkyl, C.sub.5-8 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, naphthyl, naphthyl C.sub.1-6 alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, or nitro groups; EQU D is a group --CH.sub.2 --CH(R.sub.6)--CH(R.sub.7)--C(R.sub.2)(R.sub.3)--, a group EQU --CH.sub.2 --CH(R.sub.6)--CH(R.sub.7)--CH(R.sub.8)--C(R.sub.2)(R.sub.3)--, a group EQU --CH.sub.2 --CH(R.sub.6)--CH(R.sub.7)--CH(R.sub.8)--CH(R.sub.8.sup.1)--C(R.sub.2)(R.s ub.3)-- or a group EQU --CH.sub.2 --C(R.sub.10)(R.sub.3)-- PA1 wherein R…