Process for the stereoselective synthesis of the E isomer of aryl alkyl oximes
US4158015A · kind A · utility
10Cited by
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7Claims
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Key dates
| Filing date | Aug 16, 1978 |
| Grant date | Jun 12, 1979 |
| Priority date | — |
| Expiry date | Aug 16, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/58
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Mixtures of the E and Z isomers of aryl alkyl oximes are converted to 98% or greater E isomer by a process comprising treating a solution of a mixture of E and Z isomers in an organic solvent with a protic or Lewis acid, under anhydrous conditions, to precipitate >98% pure E isomer of an immonium complex and treating (neutralizing) the precipitate with an excess of dilute organic/inorganic base, such as Na.sub.2 CO.sub.3 or NaHCO.sub.3. The E isomer of the ketoxime is a precursor for highly insecticidal ketoximinoethers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.