2,9-Dioxatricyclo[4,3,1,0.sup.3,7 ] decane derivatives, processes for their preparation and pharmaceutical compositions thereof

US4158061A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Peter W. Thies · Hannover, DE
• Samuel David · Dorval, CA

Key dates

• Filing date: Apr 19, 1978
• Grant date: Jun 12, 1979
• Expiry date: Apr 19, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3-Azidomethyl-2,9-dioxatricyclo[4,3,1,0.sup.3,7 ] decane derivatives are disclosed which exhibit analgesic, as well as antipyretic and antiphlogistic properties, and which have the formula (I) ##STR1## wherein: R.sub.1 represents alkyloxy or aralkyloxy; One of R.sub.2 and R.sub.3 is hydrogen and the other represents hydroxy, acyloxy or carbamyloxy, or R.sub.2 and R.sub.3 jointly represent oxygen; and, Y and y' each represent hydrogen or jointly form a bond, As well as pharmaceutical formulations thereof. By reducing the 3-azidomethyl compounds of formula (I), the corresponding 3-aminomethyl compounds are obtained which possess sedative properties and which are valuable intermediates for preparing 3-(mono- or dialkylaminomethyl)-2,9-dioxatricyclo[4,3,1,0.sup.3,7 ] decanes which exhibit sedative and soporific activities.