Process for the preparation of 5-(4-amino butyl)-hydantoin and/or 2-ureido-6-amino-hexanoic acid amide
US4158095A · kind A · utility
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7Claims
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Key dates
| Filing date | Jan 26, 1978 |
| Grant date | Jun 12, 1979 |
| Priority date | — |
| Expiry date | Jan 26, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/76
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved process for the preparation of 5-(4-aminobutyl)-hydantoin and/or 2-ureido-6-amino-hexanoic acid amide by the liquid phase hydrogenation of 5-(3-cyanopropyl)-hydantoin and/or 2-ureido-5-cyano-pentanoic acid amide in the presence of ammonia, hydrogen and a hydrogenation catalyst. Catalyst dissolution into the reaction medium is reduced by utilizing a hydrogenation catalyst in a solid bed form and causing the compounds to be hydrogenated to pass through such solid bed catalyst.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.