Method of producing a blood-coagulation-promoting preparation from human blood plasma

US4160025A · kind A · utility

Assignee

• Immuno Aktiengesellschaft fur chemisch-medizinische Produkte · AT

Inventors

• Johann Eibl · Wien, AT
• Otto Schwarz · Waldshut-Tiengen, DE
• Fritz Elsinger · Wien, AT

Key dates

• Filing date: Aug 8, 1977
• Grant date: Jul 3, 1979
• Expiry date: Aug 8, 1997

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In a method of producing a blood-coagulation-promoting preparation from human blood plasma, which preparation contains a new blood-coagulating substance called "FEIBA", human plasma with citrate ions is treated with water-insoluble inorganic coagulation-physiologically-surface-active substances in the absence of free calcium ions, thus generating "FEIBA", the water-insoluble substances are separated, the supernatant is treated with basic ion exchangers, wherein "FEIBA" and the coagulation factors II-VII-IX-X adhere to the ion exchangers, and "FEIBA" and the factors II-VII-IX-X are eluted and concentrated.