7[2(Substituted phenyl)2-(amino)acetamido]cephalosporin derivatives

US4162314A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rudolf Gottschlich · Reinheim, DE
• Rolf Gericke · Seeheim-Jugenheim, DE
• Horst Juraszyk · Seeheim-Jugenheim, DE
• Jurgen Seubert · Darmstadt, DE
• Wighard Strehlow · Darmstadt, DE
• Helmut Wahlig · Darmstadt, DE
• Rolf Bergmann
• Elvira Dingeldein · Darmstadt, DE

Key dates

• Filing date: Jun 13, 1977
• Grant date: Jul 24, 1979
• Expiry date: Jun 13, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D499/68
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel .beta.-lactam antibiotics are compounds of the formula: ##STR1## wherein R is alkyl of up to 6 carbon atoms or, when A is oxygen, R is hydrogen; A is oxygen or --OCO--; Z is ##STR2## R.sup.1 is hydrogen, acetoxy or S-Het; Het is 1,2,3-triazol-5-yl, 1-methyltetrazol-5-yl, 1,3,4-thiadiazol-2-yl or 2-methyl-1,3,4-thiadiazol-5-yl; and n is an integer from 0 to 8; or a readily-cleavable ester or physiologically-acceptable salt thereof.