Ring substituted pyrazino-isoquinoline derivatives and their preparation

US4162319A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Jurgen Seubert · Darmstadt, DE
• Rolf Pohlke
• Herbert Thomas
• Peter Andrews · Wuppertal, DE

Key dates

• Filing date: Aug 7, 1978
• Grant date: Jul 24, 1979
• Expiry date: Aug 7, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Isoquinolines of the formula ##STR1## wherein R.sup.1 is H, OH, alkyl; R.sup.2 is H, or an unsubstituted or substituted carbonyl, carbonyloxy or thiocarbonyl group; R.sup.3 is H, alkyl or hydroxy alkyl; R.sup.4 is H, alkyl or phenyl; R.sup.5 is O, H,H or H and alkyl, phenyl, halo or hydroxy; R.sup.6 and R.sup.7 are optional substituents; and R.sup.8 is H or alkyl, R.sup.2 being a thiocarbonyl or carbonyloxy group when R.sup.1 and R.sup.3 to R.sup.8 are H and X is O; and their physiologically acceptable salts, are antihelmintics, especially against cestodes and trematodes; some also possessing CNS activity, e.g., psychotropic and blood pressure regulating activity.