2,9-Dioxatricyclo[4,3,1,0.sup.3,7 ] decane derivatives and pharmaceutical compositions thereof

US4163055A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Peter W. Thies · Hannover, DE
• Akiji Asai · Wennigsen (Deister), DE

Key dates

• Filing date: Feb 18, 1977
• Grant date: Jul 31, 1979
• Expiry date: Feb 18, 1997

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New 2,9-dioxatricyclo[4,3,1,0.sup.3,7 ] decane derivatives are disclosed which are substituted by an amino methyl group in the C.sub.3 position, and which exhibit sedative, especially sleep improving properties, and which have the formula ##STR1## wherein R.sub.1 represents an amino group ONE OF R.sub.2 and R.sub.3 is hydrogen and the other represents hydroxy acyloxy or carbamyloxy or R.sub.2 and R.sub.3 jointly represent oxygen PA0 One of R.sub.4 and R.sub.5 is hydrogen and the other represents alkyloxy or aralkyloxy PA0 Y and y' each represent hydrogen or jointly form a bond and their pharmacologically acceptable salts, as well as pharmaceutical formulations thereof.