Patent · US Expired

Process for the preparation of tetrahydro-thieno[3,2-c]- and [2,3-c]pyridine derivatives

US4163852A · kind A · utility

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3References
3Claims
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Assignee

Inventors

Key dates

Filing dateDec 13, 1977
Grant dateAug 7, 1979
Priority date—
Expiry dateDec 13, 1997

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D495/04
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

This invention relates to a process for the preparation of tetrahydro-thieno[3,2-c]pyridine derivatives of the formula ##STR1## AND THEIR ISOMERIC TETRAHYDRO-THIENO[2,3-C]PYRIDINE DERIVATIVES IN WHICH R.sub.1 represents hydrogen, a lower alkyl or alkoxy radical, an aryl radical or an aralkyl radical; R.sub.2 and R.sub.3 represent hydrogen, halogen, a lower alkyl or alkoxy group, a di(loweralkyl)amino, nitro, cyano or acetamido group or, together with the phenyl nucleus to which they are attached, form a polycyclic aromatic ring, comprising reacting a tetrahydrothieno[3,2-c]pyridine derivative of the formula: ##STR2## OR A DERIVATIVE OF ITS ISOMER, TETRAHYDRO[2,3-C]PYRIDINE, WITH FORMALDEHYDE H-CHO and a phenol of the formula: ##STR3##

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.