Process for preparing sulfinyl chlorides from penicillin sulfoxides
US4165316A · kind A · utility
4Cited by
1References
18Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 8, 1977 |
| Grant date | Aug 21, 1979 |
| Priority date | — |
| Expiry date | Dec 8, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D205/095
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A penicillin sulfoxide ester is reacted with an N-chloro halogenating agent at a temperature of from about 75.degree. C. to about 135.degree. C. and in the presence of an alkylene oxide and calcium oxide to produce a 2-chlorosulfinylazetidin-4-one intermediate. The intermediate, upon separation from the alkylene oxide, calcium oxide, and any conversion products of both the alkylene oxide and calcium oxide, can be treated with stannic chloride to produce a 3-exomethylenecepham sulfoxide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.