Use of cyclic esters to prepare 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid
US4166061A · kind A · utility
3Cited by
1References
7Claims
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Key dates
| Filing date | Nov 2, 1977 |
| Grant date | Aug 28, 1979 |
| Priority date | — |
| Expiry date | Nov 2, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new process and intermediates for preparing 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid (ticrynafen, a diuretic agent) using as a key reaction a Friedel-Crafts acylation of an esterified 3-(2,3-dichlorophenoxy)-1,2-propanediol using a thenoyl halide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.