0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
US4166906A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 22, 1978 |
| Grant date | Sep 4, 1979 |
| Priority date | — |
| Expiry date | Jun 22, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein Z is hydroxyl esterified with a sulfonic acid residue and X is acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group of the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.