2-Methyl-6-alkyl-11-aminoalkyl-6,11-dihydro-5H-pyrido(2,3-B)(1,5)benzodia zepin-5-ones and salts thereof

US4167570A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Gunther Schmidt · Biberach, DE
• Sigfrid Puschmann
• Gunther Engelhardt

Key dates

• Filing date: Sep 28, 1977
• Grant date: Sep 11, 1979
• Expiry date: Sep 28, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 --is hydrogen, alkyl of 1 to 6 carbon atoms or benzyl; PA1 R.sub.2 --is alkyl of 1 to 6 carbon atoms, cycloalkyl of 5 to 7 carbon atoms or, together with R.sub.1 and the adjacent nitrogen atom, pyrrolidino, piperidino, hexamethyleneimino, morpholino or N'-methyl-piperazino, where each of the heterocycles may have one or two alkyl of 1 to 3 carbon atoms or one or two methoxy substituents attached thereto; PA1 R.sub.3,--r.sub.4 and R.sub.5 are each hydrogen or methyl; PA1 R.sub.6 --is alkyl of 1 to 4 carbon atoms; and PA1 A--is alkylene of 2 to 4 carbon atoms; And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as bronchospasmolytics and bronchosecretolytics.