Patent · US Expired

Ion exchanger treatment of citrate-stabilized plasma

US4170590A · kind A · utility

23Cited by

6References

7Claims

0Family size

Assignee

Biotest-Serum-Institut GmbH

Inventors

Wolfgang Stephan · Heidelberg, DE
Ronald Kotitschke · Dreieich, DE

Key dates

Filing date	Feb 6, 1978
Grant date	Oct 9, 1979
Priority date	—
Expiry date	Feb 6, 1998

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A citrate-stabilized blood plasma is frozen and thawed, the undissolved cryoprecipitate is separated and is rich in factor VIII protein. The residual liquid is treated with cation and anion exchangers, either sequentially or in admixture, to separate calcium and citrate ions therefrom. The residual plasma is then subjected to adsorption to remove a fraction which is eluted and precipitated, enriched in factors II, VII, IX and X. The liquid left from adsorption is subjected to further adsorption with silicic acid, leaving a storage-stable serum. The silicic acid is eluted to dissolve adsorbed fibrinogen which then is re-precipitated.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.