Fluoro-steroids and processes for their manufacture
US4172075A · kind A · utility
1Cited by
3References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 21, 1978 |
| Grant date | Oct 23, 1979 |
| Priority date | — |
| Expiry date | Feb 21, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/0031
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
11,12-Unsaturated 9.alpha.-fluorosteroids comprising a new class of steroid compounds are obtained by a novel process, wherein a corresponding 9.alpha.-fluoro-11.beta.-hydroxysteroid is dehydrated with a reagent of the formula F.sub.3 SX in which X denotes an amino group derived from a secondary amine. Of a particular interest among the products of the invention are compounds of the general formula IB ##STR1## in which the symbols R.sub.5 -R.sub.10 have the meanings given hereinafter; such compounds are especially useful as analogues of cortical hormones possessing antiinflammatory activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.