Pharmacodynamically active indan derivatives

US4172093A · kind A · utility

Assignee

• AB Kabi · SE

Inventors

• Barbro K. Goransson-Dahlander · Älta, SE
• Nils Ake Jonsson · Staffanstorp, SE
• Ferenc Merenyi

Key dates

• Filing date: Mar 20, 1973
• Grant date: Oct 23, 1979
• Expiry date: Mar 20, 1993

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C205/45
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to new pharmacodynamically active compounds of the general structure ##STR1## as well as the corresponding amine oxides, quarternary ammonium compounds and salts with physiologically acceptable acids. In formula I R.sup.1 signifies hydrogen, halogen or alkoxy radicals having 1-3 carbon atoms, R.sup.2 and R.sup.3 signify alkyl radicals having 1-3 carbon atoms, which togetner with the carbon atom, to which they are connected, may form a ring, A either signifies a possibly lower alkyl substituted ethylene, trimethylene or tetramethylene group, in which case D is a group ##STR2## wherein R.sup.4 and R.sup.5 individually signify hydrogen or alkyl groups having 1-4 carbon atoms, or together with the nitrogen atom form a heterocyclic ring, which in addition to said nitrogen atom may contain an oxygen atom or possibly lower alkylated amino group, or A and B taken together signify a piperidino- or N-lower alkylpiperidino group, which is connected to an indene residue in 4-position, and the broken lines signify a double bond in either endo- or exo position.