.alpha.-AMINOACYL CONTAINING NEW PEPTIDES WITH GASTRIN EFFECTS AND A PROCESS FOR THE PREPARATION THEREOF

US4172130A · kind A · utility

Assignee

• Richter Gedeon Vegyeszeti Gyar RT · HU

Inventors

• Lajos Kisfaludy · Budapest, HU
• Istvan Schon · Budapest, HU
• Vince Varro · Szeged, HU
• Laszlo Varga · Fort Collins, US
• Jozsef Nafradi · Szeged, HU

Key dates

• Filing date: Dec 29, 1977
• Grant date: Oct 23, 1979
• Expiry date: Dec 29, 1997

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides of the formula: EQU A--Trp--B--Asp--Phe--NH--Y wherein A is tert.-butoxycarbonyl-aminooxy-acyl, benzyloxycarbonyl-aminooxy-acyl, (aminooxy)-acyl, or E-aminooxy-acyl, wherein E is benzoyl or straight-chain or branched C.sub.1-5 aliphatic acyl, B is methionyl, leucyl, norleucyl, norvalyl or 2-amino-decanoyl, and Y is hydrogen or carboxymethoxy, and pharmaceutically acceptable acid-addition salts or complexes thereof have gastric-acid secretion increasing effects.