3-Nitropyrazole compounds and anti-microbial compositions

US4172136A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Herbert Berger
• Rudi Gall · Hirschberg, DE
• Kurt Stach
• Max Thiel
• Wolfgang Vomel

Key dates

• Filing date: Mar 23, 1978
• Grant date: Oct 23, 1979
• Expiry date: Mar 23, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl; PA1 R.sub.2 is hydrogen or lower alkyl; PA1 R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO-NR.sub.4 R.sub.5, in which PA1 R.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent and PA1 R.sub.5 is a hydrogen atom or a lower alkyl radical or PA1 R.sub.4 and R.sub.5 together represent a lower alkylene bridge; And the pharmacologically compatible salts thereof are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.