Decahydroquinolines, pharmaceutical compositions and methods of use
US4173636A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 8, 1978 |
| Grant date | Nov 6, 1979 |
| Priority date | — |
| Expiry date | Mar 8, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/44
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to decahydroquinoline derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 represents an alkyl or alkoxy group, a lower dialkylamino group, an optionally substituted phenyl group, a heterocyclic group; R.sup.2 represents an alkyl group, an optionally substituted phenyl group, a naphthyl group, an unsaturated heterocyclic group, an aralkyl group or an alicyclic group; and R.sup.3 represents a substituted furyl group, an aralkyl group or a group represented by the general formula: ##STR2## wherein A represents an alkylene group; Y represents an oxygen or sulphur atom, a carbonyl, carbonyl-hydroxyimino, carbonyl-hydrazono or sulphoxide group, or a group; ##STR3## n is O or an integer of from 1 to 4, with the proviso that when n is O, Y represents a carbonyl group; and R.sup.4 and R.sup.5, which are identical or different, each represent hydrogen, a halogen atom or a methyl, methoxy or acetyl group. Certain compounds of formula I have been found to possess useful analgesic properties while others have been found to be potentially useful in the treatment of high blood pressure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.