Process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro-uracil
US4174446A · kind A · utility
0Cited by
1References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 11, 1977 |
| Grant date | Nov 13, 1979 |
| Priority date | — |
| Expiry date | Oct 11, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a new process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro-uracil, also called Ftorafur, which is a very important anti-cancer compound. Said process comprises reacting 2,3-dihydrofuran with water in the presence of a catalytic amount of an acidic catalyst at a pH below 2.5, removing excess of unreacted starting materials and reacting the mixture obtained with silylated-5-fluoro-uracil is in the presence of a Friedel Crafts type catalyst uracil in an inert organic solvent. The new process has many advantages in comparison with those used so far.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.